Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors

  title={Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors},
  author={Jason D Shepherd and Gavin R Rumbaugh and Jing Wu and Shoaib Chowdhury and Niels Plath and Dietmar Kuhl and Richard L. Huganir and Paul F Worley},
Homeostatic plasticity may compensate for Hebbian forms of synaptic plasticity, such as long-term potentiation (LTP) and depression (LTD), by scaling neuronal output without changing the relative strength of individual synapses. This delicate balance between neuronal output and distributed synaptic weight may be necessary for maintaining efficient encoding of information across neuronal networks. Here, we demonstrate that Arc/Arg3.1, an immediate-early gene (IEG) that is rapidly induced by… CONTINUE READING
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Increased expression of the immediate-early gene Arc/Arg3.1 reduces AMPA receptor-mediated synaptic transmission

  • E. M. Rial Verde, J. Lee-Osourne, P. F. Worley, R. Malinow, H. T. Cline
  • Neuron 52,
  • 2006
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