Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

@article{Lyford1995ArcAG,
  title={Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites},
  author={Gregory L. Lyford and Kanato Yamagata and Walter E. Kaufmann and Carol A. Barnes and Laura K. Sanders and Neal G. Copeland and Debra J. Gilbert and Nancy A. Jenkins and Anthony A. Lanahan and Paul F. Worley},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={433-445}
}
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Activity-Regulated Gene Expression in the Brain
TLDR
A model in which neural delayed early genes (DEGs) function as late “effector” IEG proteins that directly modify the function of neurons is proposed, in which they are directly or indirectly involved in an induction of synaptic restructuring that underlies memory storage.
The accumulation of arc (an immediate early gene) mRNA by the inhibition of protein synthesis.
TLDR
It is suggested that the inhibition of protein synthesis is a crucial factor for the accumulation of Arc mRNA in L929 cells.
Phosphorylation-dependent control of Arc protein by synaptic plasticity regulator TNIK
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Characterization of each residue using site-directed mutagenesis to create S67 and T278 mutant variants revealed that TNIK action at those amino acids can strongly influence Arc’s subcellular distribution and self-assembly as capsids.
Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity
TLDR
Because Narp is rapidly regulated by neuronal activity, its lectin and growth-promoting activities are likely to play role in the modification of cellular properties that underlie long-term plasticity.
Developmental Association of the Synaptic Activity-Regulated Protein Arc with the Mouse Acrosomal Organelle and the Sperm Tail1
TLDR
A role for arc and the actin cytoskeleton in the acrosomes formation, the sperm acrosome reaction, and in sperm cell motility is supported.
Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies
Arcadlin Is a Neural Activity-regulated Cadherin Involved in Long Term Potentiation*
TLDR
Its close homology with cadherins, its rapid inducibility by neural activity, and its involvement in synaptic transmission suggest that Arcadlin may play an important role in activity-induced synaptic reorganization underlying long term memory.
Human activity-regulated cytoskeleton-associated gene (ARC) maps to chromosome 8q24
TLDR
It is demonstrated that ARC is a single copy gene located on human chromosome 8q24 close to the telomeric tip, suggesting a possible role of ARC as a candidate gene for this neurologic disorder.
mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity
TLDR
Recent studies with single-molecule imaging in live neurons confirmed and extended the role of Arc mRNA trafficking in synaptic plasticity and suggested that Arc might evolve through “domestication” of retroviruses.
Role of immediate early gene expression in cortical morphogenesis and plasticity.
TLDR
This review focuses on the neuronal immediate early gene (nIEG) response, in particular, the class of "effector" immediateEarly gene proteins that may directly modify neuronal and synaptic function.
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