Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

@article{Lyford1995ArcAG,
  title={Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites},
  author={Gregory L. Lyford and Kanato Yamagata and Walter E. Kaufmann and Carol A. Barnes and Laura K. Sanders and Neal G. Copeland and Debra J. Gilbert and Nancy A. Jenkins and Anthony A. Lanahan and Paul F. Worley},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={433-445}
}

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References

SHOWING 1-10 OF 82 REFERENCES
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
TLDR
An inducible novel member of the Ras family of small GTP-binding proteins, termed Rheb, which is rapidly and transiently induced in hippocampal granule cells by seizures and by NMDA-dependent synaptic activity in the long term potentiation paradigm.
Numerous candidate plasticity-related genes revealed by differential cDNA cloning
TLDR
A highly sensitive differential complementary DNA cloning procedure is used to identify genes that may participate in long-term plasticity, suggesting that strong neuronal activation leads to de novo synthesis of vesicular and other synaptic components.
Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites
TLDR
In situ hybridization with specific complementary DNA probes are used to show that messenger RNA for the dendrite-specific microtubule-associated protein MAP2 is present in dendrites in the developing brain.
Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268.
TLDR
The rat cDNA sequence of a zinc-finger transcription factor, Egr3/Pilot, is reported, and its regulated mRNA expression in brain is characterized, suggesting that interactions between these coregulated transcription factors may be important in defining long-term, neuroplastic responses.
Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation
TLDR
Differential screening is used to identify five immediate–early genes induced by neuronal activity that play a role in the structural changes that accompany activity-dependent plasticity and tissue-plasminogen activator (tPA) is one of these.
Growth factor-induced delayed early response genes.
TLDR
By cDNA cloning, this work has identified genes that are activated after a delay of a few hours and several hours prior to serum-induced DNA replication, which appears to be at least as complex as the immediate-early gene response to growth factors.
In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain
TLDR
The co- localization of translational machinery and high concentrations of CaM- KII in postsynaptic elements suggests an important relationship between alpha-subunit synthesis and the maintenance and plasticity of post Synaptic structures.
...
...