Arbovirus-mosquito interactions: RNAi pathway.

  title={Arbovirus-mosquito interactions: RNAi pathway.},
  author={Ken E Olson and Carol D. Blair},
  journal={Current opinion in virology},
Arthropod-borne (arbo) viruses infect hematophagous arthropods (vectors) to maintain virus transmission between vertebrate hosts. The mosquito vector actively controls arbovirus infection to minimize its fitness costs. The RNA interference (RNAi) pathway is the major antiviral response vectors use to restrict arbovirus infections. We know this because depleting RNAi gene products profoundly impacts arbovirus replication, the antiviral RNAi pathway genes undergo positive, diversifying selection… CONTINUE READING
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