Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.

@article{Bisogno1998ArachidonoylserotoninAO,
  title={Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.},
  author={T. Bisogno and D. Melck and L. De Petrocellis and Bobrov MYu and N. Gretskaya and V. Bezuglov and N. Sitachitta and W. H. Gerwick and V. Di Marzo},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={248 3},
  pages={
          515-22
        }
}
  • T. Bisogno, D. Melck, +6 authors V. Di Marzo
  • Published 1998
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis of bioactive fatty acid amides and esters such as the endogenous cannabinoid receptor ligands, anandamide (N-arachidonoyl-ethanolamine) and 2-arachidonoylglycerol, and the putative sleep inducing factor cis-9-octadecenoamide (oleamide). Most FAAH blockers developed to date also inhibit cytosolic phospholipase A2 (cPLA2) and/or bind to the CB1 cannabinoid receptor subtype. Here we report the finding of four novel FAAH inhibitors, two of… CONTINUE READING
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