Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.

  title={Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.},
  author={T. Bisogno and D. Melck and L. De Petrocellis and Bobrov MYu and N. Gretskaya and V. Bezuglov and N. Sitachitta and W. H. Gerwick and V. Di Marzo},
  journal={Biochemical and biophysical research communications},
  volume={248 3},
  • T. Bisogno, D. Melck, +6 authors V. Di Marzo
  • Published 1998
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis of bioactive fatty acid amides and esters such as the endogenous cannabinoid receptor ligands, anandamide (N-arachidonoyl-ethanolamine) and 2-arachidonoylglycerol, and the putative sleep inducing factor cis-9-octadecenoamide (oleamide). Most FAAH blockers developed to date also inhibit cytosolic phospholipase A2 (cPLA2) and/or bind to the CB1 cannabinoid receptor subtype. Here we report the finding of four novel FAAH inhibitors, two of… CONTINUE READING
    163 Citations
    Novel propanamides as fatty acid amide hydrolase inhibitors.
    • 6
    Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors.
    • S. Vandevoorde
    • Medicine, Chemistry
    • Current topics in medicinal chemistry
    • 2008
    • 69
    • PDF
    Endocannabinoid structure-activity relationships for interaction at the cannabinoid receptors.
    • P. Reggio
    • Medicine, Chemistry
    • Prostaglandins, leukotrienes, and essential fatty acids
    • 2002
    • 48
    Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors.
    • 40
    Anandamide amidohydrolase (fatty acid amide hydrolase).
    • 54
    The fatty acid amide hydrolase (FAAH).
    • 288


    Inhibitors of arachidonoyl ethanolamide hydrolysis.
    • 187
    Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor.
    • 135
    Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase.
    • 213
    Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase.
    • 111
    Brain and peripheral anandamide amidohydrolase and its inhibition by synthetic arachidonate analogues.
    • 7