Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release
@article{Freels2019ArachidonoylS, title={Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release}, author={Timothy G. Freels and Deranda B. Lester and Melloni N. Cook}, journal={Behavioural Brain Research}, year={2019}, volume={362}, pages={140-151} }
11 Citations
Chronic Effects of Indirect and Direct Cannabinoid Receptor Agonists on Addiction-Related Behaviors and Dopamine Release
- Biology, PsychologybioRxiv
- 2020
Overall, neither AA-5-HT nor ACEA induced behavioral or neurochemical changes associated with abuse liability; however, indirect mechanisms of agonizing the cannabinoid system may be a better alternative than direct mechanisms if concerned with disrupting dopamine function.
TRPV1 blockers as potential new treatments for psychiatric disorders
- Biology, PsychologyBehavioural pharmacology
- 2020
Preclinical studies yield favorable results with TRPV1 blockers in animal models of psychiatric disorders, and compounds blocking both TRpV1 and the anandamide-hydrolyzing enzyme, fatty acid amide hydrolase (FAAH), termed dual TRPv1/FAAh blockers, have been investigated with promising results.
Red-hot chili receptors: A systematic review of TRPV1 antagonism in animal models of psychiatric disorders and addiction
- Psychology, BiologyBehavioural Brain Research
- 2020
Systemic oxytocin administration alters mesolimbic dopamine release in mice
- Biology, PsychologyNeuroscience
- 2019
Impact of Cannabinoid Type 1 Receptor Modulation on Risky Decision-Making
- Biology, PsychologybioRxiv
- 2020
It is suggested that CB1R activation expedites engagement in punishment based risk- taking without affecting overall preference for risky vs. safe options, which indicates that risk preference and rate of deliberation for risk-taking are influenced by distinct neural substrates.
Cerebellar Modulation of Mesolimbic Dopamine Transmission Is Functionally Asymmetrical
- Biology, PsychologyThe Cerebellum
- 2019
It is suggested that cerebellar output can modulate mesolimbic dopamine transmission, and this modulation contributes to asymmetrically lateralized dopamine release.
Cerebellar Modulation of Mesolimbic Dopamine Transmission is Functionally Asymmetrical
- Biology, PsychologybioRxiv
- 2019
It is suggested that cerebellar output can modulate mesolimbic dopamine transmission, and this modulation contributes to asymmetrically lateralized dopamine release.
Risky decision-making predicts dopamine release dynamics in nucleus accumbens shell
- Psychology, BiologyNeuropsychopharmacology
- 2019
In vivo fixed potential amperometry in male Long-Evans rats observed a positive correlation between medial forebrain bundle-evoked dopamine release in the NACs and risky decision-making, suggesting that risk-taking is associated with elevated dopamine sensitivity.
Risky Decision-Making Predicts Dopamine Release Dynamics in Nucleus Accumbens Shell
- Psychology, BiologybioRxiv
- 2019
Excessive risky decision-making is a hallmark of addiction, promoting ongoing drug seeking despite the risk of social, financial, and physical consequences, and phasic NACs dopamine release is identified as a possible therapeutic target for alleviating the excessive risk-taking observed across multiple forms of psychopathology.
Miniature FSCV Devices: A Review
- EngineeringIEEE Sensors Journal
- 2021
The emerging miniature FSCV devices that have integrated on-board data processing capabilities to mitigate external data processing are discussed and can accelerate neurochemistry research, reducing time spent analysing data on external computers, and allowing for investigation into questions on neurotransmitter dynamics in target brain regions.
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