Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression.

@article{Muzio2006ArachidonicAS,
  title={Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression.},
  author={Giuliana Muzio and Antonella Trombetta and Marina Maggiora and Germana Martinasso and Vasilis Vasiliou and N. C. K. Lassen and Rosa Angela Canuto},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 11},
  pages={1929-38}
}
Expression of aldehyde dehydrogenase 3A1 (ALDH3A1) in certain normal and tumor cells is associated with protection against the growth inhibitory effect of reactive aldehydes generated during membrane lipid peroxidation. We found that human lung tumor (A549) cells, which express high levels of ALDH3A1 protein, were significantly less susceptible to the antiproliferative effects of 4-hydroxynonenal compared to human hepatoma HepG2 or SK-HEP-1 cells that lack ALDH3A1 expression. However, A549… CONTINUE READING

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