Arachidonic acid supplementation enhances synthesis of eicosanoids without suppressing immune functions in young healthy men

@article{Kelley1998ArachidonicAS,
  title={Arachidonic acid supplementation enhances synthesis of eicosanoids without suppressing immune functions in young healthy men},
  author={Darshan Singh Kelley and Peter C. Taylor and Gary J. Nelson and Bruce E. Mackey},
  journal={Lipids},
  year={1998},
  volume={33},
  pages={125-130}
}
This study was conducted to determine the effects of arachidonic acid (AA) supplementation on human immune response (IR) and on the secretion of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). Ten healthy men (20–38 yr) participated in the study and lived at the Metabolic Suite of the Western Human Nutrition Research Center. They were fed a basal diet (57, 27, and 16 energy percentage from carbohydrate, fat, and protein, respectively, and AA 200 mg/d) for the first 15 d of the study… 
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References

SHOWING 1-10 OF 44 REFERENCES
Increased dietary arachidonic acid enhances the synthesis of vasoactive eicosanoids in humans
TLDR
Both indicated changes in metabolite excretion may be associated with measurable effects on several physiologically significant cellular functions, such as platelet aggregation in vivo and inflammation in response to immune challenges.
Effects of low-copper diets on human immune response.
TLDR
Feeding 2.49 mg Cu/d for 24 d prevented further decreases in the indexes affected by the low-copper diet but did not restore them to the prestudy concentrations, even though plasma copper and ceruloplasmin concentrations were restored to normal.
Increased arachidonate in lipids after administration to man: Effects on prostaglandin biosynthesis
TLDR
It is concluded that the biosynthesis and function of prostaglandins can be augmented in man by oral administration of an esterified precursor fatty acid.
Short-term diets rich in arachidonic acid influence plasma phospholipid polyunsaturated fatty acid levels and prostacyclin and thromboxane production in humans.
TLDR
The results of these studies have shown that diets that contain both AA and n-3 LCP are associated with an increase in PGI2 production, without affecting TXA2 production.
The influence of dietary essential fatty acids on rat immunocompetent cell prostaglandin synthesis and mitogen-induced blastogenesis.
TLDR
The results suggest that mitogenesis is not influenced by the diet-induced change in immune cell PGE2 synthesizing capacity, and enhanced [3H]thymidine incorporation was associated with a greater degree of saturation of dietary fat.
The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism.
TLDR
Significant evidence is provided that the inhibition of lymphocyte proliferation by fatty acids is independent of the production of eicosanoids, and other mechanisms must be investigated if the effect of fatty acids upon lymphocytes proliferation is to be understood at a biochemical level.
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