Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats

  title={Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats},
  author={Taisuke Fukaya and Takumi Gondaira and Yasuto Kashiyae and Susumu Kotani and Yoshiyuki Ishikura and Shigeaki Fujikawa and Yoshinobu Kiso and Manabu Sakakibara},
  journal={Neurobiology of Aging},
Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in Tg2576 Mice.
It is reported here that 4 months of treatment of Tg2576 mice with an arachidonic acid (ARA)- or a docosahexaenoic acid (DHA)-containing (ARA+ or DHA+) diet prevented memory impairment at 13 months of age, and suggest that not only the DHA+ diet, but also the ARA+ diet could prevent cognitive dysfunction in Tg 2576 mice through the alteration of AβPP processing.
Expression of fatty acid‐binding proteins in adult hippocampal neurogenic niche of postischemic monkeys
The expression of FABP 3, 5, and 7 in the SGZ supports a role of astrocyte‐ and/or neural progenitor‐derived FABPs as components of the molecular machine regulating the progenitors cell niche in the adult primate brain.
Inhibition of phospholipase A2 in rat brain modifies different membrane fluidity parameters in opposite ways
Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
The present review analyzes the neuroprotective role of DHA and AA in the extreme stages of life, emphasizing the importance of these LCPUFA during the first year of life and in the developing/prevention of neurodegenerative diseases associated with aging.
Effects of PUFA, Especially Arachidonic Acid on the Aged Brain Function and It’s Mechanisms
The effects of PUFA on cognitive function revealed by the results of animal experiments from the view point of behavior, electrophysiology, opto-physiology, membrane-biophysics, immunohistochemistry, and biochemistry are summarized in this review.
Arachidonic Acid Drives Postnatal Neurogenesis and Elicits a Beneficial Effect on Prepulse Inhibition, a Biological Trait of Psychiatric Illnesses
The potential benefit of ARA in ameliorating PPI deficits relevant to psychiatric disorders is suggested and the effect may be correlated with augmented postnatal neurogenesis.


Arachidonic acid improves aged rats' spatial cognition
Learning-induced changes in brain membrane cholesterol and fluidity: implications for brain aging.
It is postulate that upon the learning impact, brain membranes undergo definite changes in the lipid membrane phase which participate in the transduction of the learning process into biochemical templates.
Dietary Supplementation with Vitamin E Reverses the Age-related Deficit in Long Term Potentiation in Dentate Gyrus*
The observation that α-tocopherol reverses these changes is consistent with the hypothesis that some age-related changes in hippocampus might derive from oxidative stress and may be responsible for the deficit in long term potentiation in aged rats.
Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids
The results are interpreted in terms of the roles of different phospholipid molecular species in cognitive functions coupled with differential responsiveness of the genetic machinery of neurons to n-3 polyunsaturated fatty acids.
Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed.
The data presented indicate that dietary supplementation in aged rats restored the concentrations of arachidonic acid and docosahexanoic acid in hippocampal preparations to those observed in tissue prepared from young rats, and supports the view that an age-related increase in reactive oxygen species production is linked with the decrease in polyunsaturated fatty acids.
Docosahexaenoic acid improves long‐term potentiation attenuated by phospholipase A2 inhibitor in rat hippocampal slices
The results suggest that DHA is crucial for the induction of LTP and that endogenously released DHA during tetanus is sufficient to trigger the formation ofLTP.
Effect of L-α-glycerylphosphorylcholine on muscarinic receptors and membrane microviscosity of aged rat brain
Membrane Arachidonic Acid Concentration Correlates with Age and Induction of Long‐term Potentiation in the Dentate Gyrus in the Rat
A correlation between membrane arachidonic acid concentration, glutamate release and ability to sustain LTP in aged animals is indicated and a correlation between potassium‐stimulated, calcium‐dependent release of glutamate was decreased in aged compared with young animals.