Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current

THE M-current (IM) is a time- and voltage-dependent K+ current that persists at slightly depolarized membrane potentials1. IM is reduced by muscarinic cholinergic agonists and certain peptides, and is thought to be responsible in part for the slow and late slow excitatory postsynaptic potentials in sympathetic neurons1–3. Recently, we reported4 that IM in… CONTINUE READING