Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current

@article{Schweitzer1990ArachidonicAM,
  title={Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current},
  author={Paul H. Schweitzer and Samuel G. Madamba and George Robert Siggins},
  journal={Nature},
  year={1990},
  volume={346},
  pages={464-467}
}
  • Paul H. Schweitzer, Samuel G. Madamba, George Robert Siggins
  • Published in Nature 1990
  • Biology, Medicine
  • THE M-current (IM) is a time- and voltage-dependent K+ current that persists at slightly depolarized membrane potentials1. IM is reduced by muscarinic cholinergic agonists and certain peptides, and is thought to be responsible in part for the slow and late slow excitatory postsynaptic potentials in sympathetic neurons1–3. Recently, we reported4 that IM in hippocampal neurons was also augmented by somatostatin-14 and -28 suggesting that two different receptors reciprocally regulate one neuronal… CONTINUE READING

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