Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors.

@article{Campbell2007ArachidonicAM,
  title={Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors.},
  author={William Campbell and John R Falck},
  journal={Hypertension},
  year={2007},
  volume={49 3},
  pages={590-6}
}
The endothelium regulates vascular tone through the release of a number of soluble mediators, including NO, prostaglandin I2, and endothelium-derived hyperpolarizing factor. Epoxyeicosatrienoic acids are cytochrome P450 epoxygenase metabolites of arachidonic acid. They are synthesized by the vascular endothelium and open calcium-activated potassium channels, hyperpolarize the membrane, and relax vascular smooth muscle. Endothelium-dependent relaxations to acetylcholine, bradykinin, and shear… CONTINUE READING
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Epoxyeicosatrienoic acids mediate flow - induced dilation of bovine small coronary arteries

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Epoxyeicosatrienoic acids mediate flow-induced dilation of bovine small coronary arteries. Hypertension

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Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in human essential hypertensive patients

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