Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics.

@article{Schmid1999ArachidonicAM,
  title={Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics.},
  author={M. Schmid and U. G{\"o}de and D. Sch{\"a}fer and M. Wigand},
  journal={Acta oto-laryngologica},
  year={1999},
  volume={119 2},
  pages={
          277-80
        }
}
Aspirin intolerance (AI) is characterized by polypous rhinosinusitis, bronchial asthma and adverse reactions to aspirin. The common intolerance to all cyclo-oxygenase inhibitors allows us to focus study of the pathogenesis of AI on the metabolism of arachidonic acid (AA). We studied the metabolism of AA in nine aspirin intolerant asthmatics (AIA) and eight healthy volunteers (controls) by measuring prostaglandin E2 (PGE2) and peptido-leukotrienes (pLT = LTC4/D4/E4) in nasal tissue and… Expand
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