Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models.

@article{Bosetti2007ArachidonicAM,
  title={Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models.},
  author={Francesca Bosetti},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 3},
  pages={
          577-86
        }
}
  • Francesca Bosetti
  • Published in Journal of neurochemistry 2007
  • Medicine, Biology
  • The arachidonic acid (AA) cascade involves the release of AA from the membrane phospholipids by a phospholipase A(2), followed by its subsequent metabolism to bioactive prostanoids by cyclooxygenases coupled with terminal synthases. Altered brain AA metabolism has been implicated in neurological, neurodegenerative, and psychiatric disorders. The development of genetically altered mice lacking specific enzymes of the AA cascade has helped to elucidate the individual roles of these enzymes in… CONTINUE READING

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