Arachidonic acid metabolism in airway epithelial cells.

  title={Arachidonic acid metabolism in airway epithelial cells.},
  author={Michael J Holtzman},
  journal={Annual review of physiology},
Airway epithelial cells carry out their physiologic role in part by activating phospholipase-fatty acid oxygenation pathways. Recent discoveries include the facts that (a) airway epithelial cells contain abundant stores of fatty acid substrates, including arachidonic acid, for oxygenation, (b) the cells release arachidonic acid upon activation of specific phospholipases, (c) the cells contain novel cyclooxygenases and lipoxygenases at high levels relative to other cell types, and (d) some of… CONTINUE READING


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