Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation.

@article{Levick2007ArachidonicAM,
  title={Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation.},
  author={Scott P Levick and David C. Loch and Stephen M. Taylor and Joseph S Janicki},
  journal={Journal of immunology},
  year={2007},
  volume={178 2},
  pages={
          641-6
        }
}
An increase in left ventricular collagen (cardiac fibrosis) is a detrimental process that adversely affects heart function. Strong evidence implicates the infiltration of inflammatory cells as a critical part of the process resulting in cardiac fibrosis. Inflammatory cells are capable of releasing arachidonic acid, which may be further metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450 monooxygenase enzymes to biologically active products, including PGs, leukotrienes… CONTINUE READING
Highly Cited
This paper has 30 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations