Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs.

@article{Seeger1987ArachidonicAL,
  title={Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs.},
  author={Werner Seeger and Michael Dieter Menger and Dieter Walmrath and Guillaume Becker and Friedrich Grimminger and Heinz Neuhof},
  journal={The American review of respiratory disease},
  year={1987},
  volume={136 4},
  pages={964-72}
}
Products of arachidonic acid (AA) pathways have repeatedly been implicated in acute lung vascular injury with respiratory distress. In blood-free perfused isolated rabbit lungs, AA endogenously released or exogenously applied causes an acute pressor response, mediated by metabolites of the cyclooxygenase pathway including thromboxane A2. Moreover, bolus application of AA (final concentration, 100 microM in the recirculating buffer) during an acute hydrostatic challenge was recently noted to… CONTINUE READING
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