Arachidonic acid inhibits capacitative calcium entry in rat thymocytes and human neutrophils.

@article{AlonsoTorre1997ArachidonicAI,
  title={Arachidonic acid inhibits capacitative calcium entry in rat thymocytes and human neutrophils.},
  author={Sara Raquel Alonso-Torre and Javier Garc{\'i}a-Sancho},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1328 2},
  pages={207-13}
}
Emptying the intracellular Ca2+ stores by treatment with the endomembrane Ca2+-ATPase inhibitor thapsigargin activates capacitative Ca2+ entry (CCE). This can be evidenced in fura-2-loaded cells by an increase of [Ca2+]i or by an acceleration of Mn2+ entry. Micromolar concentrations of arachidonic acid inhibited CCE induced by treatment with thapsigargin in rat thymocytes and in human neutrophils. This inhibitory action was shared by other unsaturated fatty acids, but not by the saturated… CONTINUE READING