Corpus ID: 17648227

Arachidonic acid formed by peroxisomal beta-oxidation of 7,10,13,16-docosatetraenoic acid is esterified into 1-acyl-sn-glycero-3-phosphocholine by microsomes.

@article{Baykousheva1994ArachidonicAF,
  title={Arachidonic acid formed by peroxisomal beta-oxidation of 7,10,13,16-docosatetraenoic acid is esterified into 1-acyl-sn-glycero-3-phosphocholine by microsomes.},
  author={Svetla P. Baykousheva and Devanand L. Luthria and Howard W. Sprecher},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 28},
  pages={
          18390-4
        }
}
Peroxisomal beta-oxidation of linoleic acid and arachidonic acid was depressed when 1-palmitoyl-sn-glycero-3-phosphocholine and microsomes were included in incubations. This reduction was due to the esterification of the substrate into the acceptor by microsomal 1-acyl-sn-glycero-3- phosphocholine acyltransferase. The first cycle of the beta-oxidation of 7,10,13,16-docosatetraenoic acid was independent of 1-acyl-sn-glycero-3-phosphocholine and microsomes. However, when arachidonate was produced… Expand
16 Citations
Double Bond Removal from Odd-numbered Carbons during Peroxisomal β-Oxidation of Arachidonic Acid Requires both 2,4-Dienoyl-CoA Reductase and Δ3,5,Δ2,4-Dienoyl-CoA Isomerase (*)
The pathway for the peroxisomal β-oxidation of arachidonic acid (5,8,11,14-20:4) was elucidated by comparing its metabolism with 4,7,10-hexadecatrienoic acid (4,7,10-16:3) and 5,8-tetradecadienoicExpand
Metabolites produced during the peroxisomal beta-oxidation of linoleate and arachidonate move to microsomes for conversion back to linoleate.
TLDR
The results show that when 5,8-14:2 and 4,7,10-16:3 are produced by peroxisomal beta-oxidation they can be further degraded to hexanoyl-CoA or move to microsomes for conversion back to linoleate, which is a precursor of arachidonate. Expand
Analysis of the acyl-CoAs that accumulate during the peroxisomal beta-oxidation of arachidonic acid and 6,9,12-octadecatrienoic acid.
The biosynthesis of 4,7,10,13,16-22:5 and 4,7,10,13,16,19-22:6 requires that when 6,9,12,15,18-24:5 and 6,9,12,15,18,21-24:6 are produced in microsomes they must move to peroxisomes for partialExpand
Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal process.
  • H. Sprecher, Q. Chen
  • Biology, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
  • 1999
TLDR
These findings suggest that there may be considerably more recycling of fatty acids between peroxisomes and the endoplasmic reticulum than was previously recognized. Expand
Conversion of arachidonic acid to tetradecadienoic acid by peroxisomal oxidation.
TLDR
It is demonstrated that 14:2 can be synthesized from arachidonic acid, that this oxidative process occurs in the peroxisomes, and that the pathway does not function in Zellweger's syndrome and similar diseases where there is a genetic deficiency in peroxISomal beta-oxidation. Expand
Role of peroxisomal oxidation in the conversion of arachidonic acid to eicosatrienoic acid in human skin fibroblasts.
TLDR
Findings suggest that some of the 16:3 produced from arachidonic acid by peroxisomal beta-oxidation can be recycled and that this recycling process constitutes a novel pathway for the conversion of arachidsonic acid to 20:3 in human fibroblasts. Expand
Regulation of the Biosynthesis of 4,7,10,13,16,19-Docosahexaenoic Acid*
TLDR
When microsomes and 1-acyl-GPC were included in incubations, the preferred metabolic fate of acids, with their first double bond at either positions 4 or 5, was to move out of peroxisomes for esterification into the acceptor rather than serving as substrates for continued β-oxidation. Expand
Peroxisomal‐microsomal communication in unsaturated fatty acid metabolism
TLDR
It was shown that the preferred metabolic fate of arachidonate, when added directly to incubations, or generated via β‐oxidation, was esterification by microsomal 1‐acyl‐GPC acyltransferase, rather than continued peroxisomal β-oxidation. Expand
New advances in fatty-acid biosynthesis.
TLDR
The biosynthesis of both 22:5(n-6) and 22:6( n-3) thus requires the extensive movement of fatty acids between subcellular compartments, and peroxisomes chain-shorten fatty acids, which then move back to the endoplasmic reticulum for esterification. Expand
Differences in the regulation of biosynthesis of 20- versus 22-carbon polyunsaturated fatty acids.
TLDR
The addition of fatty acids to the diet would appear to be a way to increase the amount of arachidonate or 20:5(n-3) that is produced and potentially made available for esterification into membrane lipids. Expand
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