Arachidonic acid-evoked Ca2+ signals promote nitric oxide release and proliferation in human endothelial colony forming cells.

@article{Zuccolo2016ArachidonicAC,
  title={Arachidonic acid-evoked Ca2+ signals promote nitric oxide release and proliferation in human endothelial colony forming cells.},
  author={Estella Zuccolo and S. Dragoni and V. Poletto and P. Catarsi and D. Guido and A. Rappa and M. Reforgiato and F. Lodola and D. Lim and V. Rosti and G. Guerra and F. Moccia},
  journal={Vascular pharmacology},
  year={2016},
  volume={87},
  pages={
          159-171
        }
}
Arachidonic acid (AA) stimulates endothelial cell (EC) proliferation through an increase in intracellular Ca2+ concentration ([Ca2+]i), that, in turn, promotes nitric oxide (NO) release. AA-evoked Ca2+ signals are mainly mediated by Transient Receptor Potential Vanilloid 4 (TRPV4) channels. Circulating endothelial colony forming cells (ECFCs) represent the only established precursors of ECs. In the present study, we, therefore, sought to elucidate whether AA promotes human ECFC (hECFC… Expand
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