Arachidonic acid elevates cytosolic free calcium concentration in rat anterior pituitary cells

@article{Knepel1988ArachidonicAE,
  title={Arachidonic acid elevates cytosolic free calcium concentration in rat anterior pituitary cells},
  author={Willhart Knepel and Christof Sch{\"o}fl and Doris M. G{\"o}tz},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={338},
  pages={303-309}
}
Arachidonic acid is liberated from phospholipids by various hypothalamic releasing hormones and may be involved in stimulus-secretion coupling in rat adenohypophysis. In the present study, the effect of exogenous arachidonic acid on calcium homeostasis in rat anterior pituitary cells was investigated in vitro. Arachidonic acid markedly stimulated the release of various anterior pituitary hormones (beta-endorphin, luteinizing hormone, growth hormone). Arachidonic acid (10 μmol/l) decreased the… CONTINUE READING