Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα--14-3-3ζ] association.

@article{Wal2012ArachidonicAD,
  title={Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα--14-3-3ζ] association.},
  author={Dianne E. van der Wal and Eelo Gitz and Vivian X Du and Kimberly S L Lo and Cornelis A. Koekman and Sabine Versteeg and Jan Willem N. Akkerman},
  journal={Haematologica},
  year={2012},
  volume={97 10},
  pages={1514-22}
}
BACKGROUND Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, Bad activation and apoptosis. DESIGN AND METHODS We investigated whether arachidonic acid, which also binds 14-3-3ζ, contributes to coldinduced apoptosis. RESULTS Cold storage activated P38-mitogen-activated protein kinase and released arachidonic… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Evidence for the involvement of ERK in cold-induced injury [abstract

  • V Laszlo, U. Rauen
  • Cryobiology
  • 2010

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