Arachidonic acid as a retrograde signal controlling growth and dynamics of retinotectal arbors.

@article{Leu2008ArachidonicAA,
  title={Arachidonic acid as a retrograde signal controlling growth and dynamics of retinotectal arbors.},
  author={Byunghee Leu and John T. Schmidt},
  journal={Developmental neurobiology},
  year={2008},
  volume={68 1},
  pages={18-30}
}
In the developing visual system, correlated presynaptic activity between neighboring retinal ganglion cells (RGC) stabilizes retinotopic synapses via a postsynaptic NMDAR (N-methyl-D-aspartate receptor)-dependent mechanism. Blocking NMDARs makes individual axonal arbors larger, which underlies an unsharpened map, and also increases branch turnover, as if a stabilizing factor from the postsynaptic partner is no longer released. Arachidonic acid (AA), a candidate retrograde stabilizing factor, is… CONTINUE READING

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