Arachidonic acid affects biofilm formation and PGE2 level in Candida albicans and non-albicans species in presence of subinhibitory concentration of fluconazole and terbinafine.

@article{Mishra2014ArachidonicAA,
  title={Arachidonic acid affects biofilm formation and PGE2 level in Candida albicans and non-albicans species in presence of subinhibitory concentration of fluconazole and terbinafine.},
  author={Nripendra Nath Mishra and Shakir Ali and Praveen Kumar Shukla},
  journal={The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases},
  year={2014},
  volume={18 3},
  pages={
          287-93
        }
}
  • N. Mishra, Shakir Ali, P. Shukla
  • Published 1 May 2014
  • Biology, Medicine
  • The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Candida albicans utilizes arachidonic acid (AA) released during the course of infection (Candidiasis) from phospholipids of infected host cell membranes and synthesizes extracellular prostaglandin(s) which play an important role in hyphae formation and host cell damage. C. albicans biofilms secrete significantly more prostaglandin(s) and evidence suggests that Candida biofilms have dramatically reduced susceptibility to majority of antifungal drugs. AA influences the saturation level of lipids… 
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