Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

@article{Dixon2004ArachidonicAP,
  title={Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.},
  author={G. Dixon and J. Nolan and N. Mcclenaghan and P. Flatt and P. Newsholme},
  journal={Clinical science},
  year={2004},
  volume={106 2},
  pages={
          191-9
        }
}
Insulin-resistant states such as obesity can result in an increase in the function and mass of pancreatic beta-cells, so that insulin secretion is up-regulated and Type II diabetes does not develop. However, expansion of beta-cell mass is not indefinite and may well decrease with time. Changes in circulating concentrations of nutritional factors, such as fatty acids and/or glucose, may lead to a reduction in beta-cell mass in vivo. Few previous studies have attempted to explore the interplay… Expand
Amino Acid Metabolism, β-Cell Function, and Diabetes
Nutrient regulation of insulin secretion and beta-cell functional integrity.
Differential regulation by fatty acids of protein histidine phosphorylation in rat pancreatic islets
  • A. Kowluru
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • 2004
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References

SHOWING 1-10 OF 47 REFERENCES
Arachidonic acid-induced insulin secretion from rat islets of Langerhans.
...
1
2
3
4
5
...