Arachidonic Acid Regulates the Phosphoinositide Signal Transduction Pathway in Submandibular Acinar Cells

@article{Chung1992ArachidonicAR,
  title={Arachidonic Acid Regulates the Phosphoinositide Signal Transduction Pathway in Submandibular Acinar Cells},
  author={H. Chung and N. Fleming},
  journal={Journal of Dental Research},
  year={1992},
  volume={71},
  pages={1462 - 1467}
}
Modulation of the phosphoinositide signal transduction pathway by arachidonic acid (AA) in collagenase-dispersed rat submandibular acinar cells was investigated. The muscarinic agonist, carbachol, stimulated PIP2 hydrolysis and the generation of IP 3 to five-fold the control levels. This response was inhibited by 75% on pre-treatment of cells with AA. The AA inhibitory effect was not duplicated by a range of prostaglandins and leukotrienes and was not reversed by blockers of the cyclo-oxygenase… Expand
Regulation of phosphatidylinositol kinases by arachidonic acid in rat submandibular gland cells
TLDR
It is proposed that AA regulates phosphoinositide cycle activity in submandibular gland cells by acting as a noncompetitive inhibitor of PI 4-kinase and PI(4)P 5-kinases. Expand
Muscarinic regulation of phospholipase D and its role in arachidonic acid release in rat submandibular acinar cells
The characteristics of muscarinic cholinergic-induced phospholipase D (PLD) activation, and the involvement of the enzyme in the release of arachidonic acid were examined in rat submandibular acinarExpand
Arachidonic Acid Stimulates Intracellular Calcium Mobilization and Regulates Protein Synthesis, ATP Levels, and Mucin Secretion in Submandibular Gland Cells
TLDR
It is concluded that arachidonic acid acts as a regulator of central synthetic/secretory processes in mucous acinar cells of rat submandibular gland and suggested that at least some of its effects may be secondary to its calcium-mobilizing action. Expand
Arachidonic Acid Inhibition of Muscarinic Receptor-Mediated Nitric Oxide Production Occurs at the Level of Calcium Mobilization in Chinese Hamster Ovary Cells
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Investigation of the effects of exogenous AA on signal transduction of M1 muscarinic acetylcholine receptors in a model system of stably transfected Chinese hamster ovary cells supports the concept that AA concentration-dependently inhibits receptor-mediated NO production at the level of calcium mobilization. Expand
Phosphorylation of protein kinase B, the key enzyme in insulin-signaling cascade, is enhanced in linoleic and arachidonic acid-treated HT29 and HepG2 cells.
TLDR
It is demonstrated that plasma membrane lipid bilayer enrichment with LNA or ARA treatment enhances insulin action by AKT activation, and consequently on the insulin-signaling pathway and specifically AKT phosphorylation. Expand

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