Arachidonic Acid Inhibition of Muscarinic Receptor-Mediated Nitric Oxide Production Occurs at the Level of Calcium Mobilization in Chinese Hamster Ovary Cells

@article{Linden2004ArachidonicAI,
  title={Arachidonic Acid Inhibition of Muscarinic Receptor-Mediated Nitric Oxide Production Occurs at the Level of Calcium Mobilization in Chinese Hamster Ovary Cells},
  author={D. R. Linden and E. El-Fakahany},
  journal={Neurochemical Research},
  year={2004},
  volume={27},
  pages={441-449}
}
Strong evidence supports that nitric oxide (NO) alters cell signaling pathways involving arachidonic acid (AA). Little is known, however, about the reciprocal modulation of nitrergic pathways by AA. The effects of exogenous AA on signal transduction of M1 muscarinic acetylcholine receptors were investigated in a model system of stably transfected Chinese hamster ovary cells. AA concentration-dependently inhibited the effects of carbachol in producing NO (IC50 = 191 μM) but did not alter… Expand
Section I. The cholinergic system.
  • J. Smythies
  • Medicine, Biology
  • International review of neurobiology
  • 2005
The Interactions of Nitric Oxide and Acetylcholine on Penicillin-Induced Epilepsy in Rats

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