Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling.

@article{Lammers1996Arachidonate5A,
  title={Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling.},
  author={C H Lammers and Paul Schweitzer and Patricia Facchinetti and J. M. Arrang and Samuel G. Madamba and George Robert Siggins and Danlele Piomelli},
  journal={Journal of neurochemistry},
  year={1996},
  volume={66 1},
  pages={147-52}
}
5-Lipoxygenase-activating protein (FLAP) is an 18-kDa integral membrane protein required, in peripheral cells, for the activation of 5-lipoxygenase (5-LO) and for the resulting synthesis of leukotrienes from arachidonic acid. In the brain, the leukotrienes have been implicated in several pathophysiological events and in the electrophysiological effect of… CONTINUE READING