Arachidonate 12-lipoxygenases with reference to their selective inhibitors.

  title={Arachidonate 12-lipoxygenases with reference to their selective inhibitors.},
  author={Shozo Yamamoto and Michiko Katsukawa and Ayumi Nakano and Emi Hiraki and Kohji Nishimura and Mitsuo Jisaka and Kazushige Yokota and Natsuo Ueda},
  journal={Biochemical and biophysical research communications},
  volume={338 1},
Lipoxygenase is a dioxygenase recognizing a 1-cis,4-cis-pentadiene of polyunsaturated fatty acids. The enzyme oxygenates various carbon atoms of arachidonic acid as a substrate and produces 5-, 8-, 12- or 15-hydroperoxyeicosatetraenoic acid with a conjugated diene chromophore. The enzyme is referred to as 5-, 8-, 12- or 15-lipoxygenase, respectively. Earlier we found two isoforms of 12-lipoxygenase, leukocyte- and platelet-type enzymes, which were distinguished by substrate specificity… CONTINUE READING

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