Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells.

  title={Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells.},
  author={Yumi Takahashi and Golla Ramalinga Reddy and Natsuo Ueda and Shozo Yamamoto and Seiji Arase},
  journal={The Journal of biological chemistry},
  volume={268 22},
A homogenate of epidermal cells isolated from human skin converted arachidonic acid to 12S-hydroxy-5, 8,10,14-eicosatetraenoic acid and 15-hydroxy-5, 8,11,13-eicosatetraenoic acid as the main lipoxygenase products. The production of these hydroxy acids was not stimulated by the addition of 1 mM NADPH required for cytochrome P-450 reaction, but inhibited by 65-75% with 40 microM nordihydroguaiaretic acid, a nonspecific lipoxygenase inhibitor. In addition to these lipoxygenase products, the… CONTINUE READING


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The 8 th International Conference on Pmstnehndinv and Related Compounds

  • C.-C Ning, M. T. Lin, J.-D. Huang
  • 1992

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