Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei.

@article{Smith1997ArabinoseAD,
  title={Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei.},
  author={Michael D. Smith and Brian Angus and Vanaporn Wuthiekanun and Nicholas J White},
  journal={Infection and immunity},
  year={1997},
  volume={65 10},
  pages={4319-21}
}
Two distinct types of Burkholderia pseudomallei, differentiated by the ability to assimilate L-arabinose but with similar morphologies and antigenicities, can be isolated from soil in Thailand. Approximately 25% of soil isolates from northeast Thailand were arabinose assimilators (Ara+), but in 1,200 sequentially studied patients, only arabinose "nonassimilators" (Ara-) caused melioidosis (P < 0.0001). In a murine model, there was a striking difference in virulence between Ara- and Ara+ B… CONTINUE READING