Arabidopsis meiotic crossover hotspots overlap with H2A.Z nucleosomes at gene promoters

  title={Arabidopsis meiotic crossover hotspots overlap with H2A.Z nucleosomes at gene promoters},
  author={Kyuha Choi and Xiaohui Zhao and Krystyna A. Kelly and Oliver Venn and James D Higgins and Nataliya E. Yelina and Thomas J. Hardcastle and Piotr A Ziolkowski and Gregory P. Copenhaver and F Christopher H Franklin and Gilean McVean and Ian R. Henderson},
  booktitle={Nature Genetics},
PRDM9 directs human meiotic crossover hot spots to intergenic sequence motifs, whereas budding yeast hot spots overlap regions of low nucleosome density (LND) in gene promoters. To investigate hot spots in plants, which lack PRDM9, we used coalescent analysis of genetic variation in Arabidopsis thaliana. Crossovers increased toward gene promoters and terminators, and hot spots were associated with active chromatin modifications, including H2A.Z, histone H3 Lys4 trimethylation (H3K4me3), LND and… CONTINUE READING
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