Arabidopsis glyoxalase II contains a zinc/iron binuclear metal center that is essential for substrate binding and catalysis.

@article{Zang2001ArabidopsisGI,
  title={Arabidopsis glyoxalase II contains a zinc/iron binuclear metal center that is essential for substrate binding and catalysis.},
  author={Trinity Zang and Dominic Hollman and Patrick Crawford and Michael W Crowder and Christopher A Makaroff},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 7},
  pages={4788-95}
}
Glyoxalase II participates in the cellular detoxification of cytotoxic and mutagenic 2-oxoaldehydes. Because of its role in chemical detoxification, glyoxalase II has been studied as a potential anti-cancer and/or anti-protozoal target; however, very little is known about the active site and reaction mechanism of this important enzyme. To characterize the active site and kinetic mechanism of the enzyme, a detailed mutational study of Arabidopsis glyoxalase II was conducted. Data presented here… CONTINUE READING
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