Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor.

@article{Gendron2012ArabidopsisCC,
  title={Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor.},
  author={Joshua M Gendron and Jos{\'e} L Pruneda-Paz and Colleen J Doherty and Andrew M. Gross and Shannon Kang and Steve A Kay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 8},
  pages={
          3167-72
        }
}
The first described feedback loop of the Arabidopsis circadian clock is based on reciprocal regulation between Timing of CAB Expression 1 (TOC1) and Circadian Clock-associated 1 (CCA1)/late elongated hypocotyl (LHY). CCA1 and LHY are Myb transcription factors that bind directly to the TOC1 promoter to negatively regulate its expression. Conversely, the activity of TOC1 has remained less well characterized. Genetic data support that TOC1 is necessary for the reactivation of CCA1/LHY, but there… CONTINUE READING

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