Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles.

@article{Kolesnikova2007ArabidopsisCC,
  title={Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles.},
  author={Mariya D. Kolesnikova and William K Wilson and David A Lynch and Allie C. Obermeyer and Seiichi P T Matsuda},
  journal={Organic letters},
  year={2007},
  volume={9 25},
  pages={
          5223-6
        }
}
We establish by heterologous expression that the Arabidopsis thaliana oxidosqualene cyclase At1g78955 (CAMS1) makes camelliol C (98%), achilleol A (2%), and beta-amyrin (0.2%). CAMS1 is the first characterized cyclase that generates predominantly a monocyclic triterpene alcohol. Phylogenetic analysis shows that CAMS1 evolved from enzymes that make pentacycles, thus revealing that its pentacyclic beta-amyrin byproduct is an evolutionary relic. Sequence alignments support prior suggestions that… 
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