Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling.

  title={Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling.},
  author={Erik A van der Biezen and Jiandong Sun and Mark J Coleman and Mervyn Bibb and Jonathan D. G. Jones},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 7},
Arabidopsis RPP5 is a member of a large class of pathogen resistance genes encoding nucleotide-binding sites and leucine-rich repeat domains. Yeast two-hybrid analysis showed that RPP5 specifically interacts with At-RSH1, an Arabidopsis RelA/SpoT homolog. In Escherichia coli, RelA and SpoT determine the level of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), which are the effector nucleotides of the bacterial stringent response. Functional analysis in E. coli and in… CONTINUE READING

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