Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(∗)-mediated silencing of a Golgi-localized SNARE gene, MEMB12.

@article{Zhang2011ArabidopsisA2,
  title={Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(∗)-mediated silencing of a Golgi-localized SNARE gene, MEMB12.},
  author={Xiaoming Zhang and Hongwei Zhao and Shang Gao and Wei-chi Wang and Surekha Katiyar-Agarwal and Hsien-Da Huang and Natasha V. Raikhel and Hailing Jin},
  journal={Molecular cell},
  year={2011},
  volume={42 3},
  pages={356-66}
}
Argonaute (AGO) proteins are critical components of RNA silencing pathways that bind small RNAs and mediate gene silencing at their target sites. We found that Arabidopsis AGO2 is highly induced by the bacterial pathogen Pseudomonas syringae pv. tomato (Pst). Further genetic analysis demonstrated that AGO2 functions in antibacterial immunity. One abundant species of AGO2-bound small RNA is miR393b(∗), which targets a Golgi-localized SNARE gene, MEMB12. Pst infection downregulates MEMB12 in a… CONTINUE READING
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