AraC/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimurium.

@article{Akbar2003AraCXylSFM,
  title={AraC/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimurium.},
  author={Samina Akbar and Lisa M. Schechter and C Phoebe Lostroh and Catherine A. A. Lee},
  journal={Molecular microbiology},
  year={2003},
  volume={47 3},
  pages={715-28}
}
Salmonella typhimurium is a Gram-negative enteric pathogen that can infect intestinal epithelial cells and induce inflammation of the intestinal mucosa. These processes are mediated by a type III secretion system (TTSS), which is encoded on Salmonella pathogenicity island 1 (SPI1). Previous studies showed that four SPI1-encoded transcriptional regulators, HilD, HilC, HilA and InvF, act in an ordered fashion to co-ordinately activate expression of the SPI1 TTSS. HilD and HilC derepress hilA… CONTINUE READING

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