Ara-C differentially affects multiprotein forms of human cell DNA polymerase

@article{Wills2000AraCDA,
  title={Ara-C differentially affects multiprotein forms of human cell DNA polymerase},
  author={Philip W. Wills and Robert J. Hickey and Linda H. Malkas},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2000},
  volume={46},
  pages={193-203}
}
Purpose: The antimetabolite 1-β-d-arabinofuranosylcytosine (ara-C) has proven to be one of the most effective agents available for the treatment of acute leukemia although the precise mechanism by which ara-C induces cytotoxicity remains unclear. Our laboratory has previously isolated from human cells a DNA replication complex, termed the DNA synthesome, which is fully competent to orchestrate, in vitro, all of the reactions required to efficiently and faithfully replicate DNA. Using this… CONTINUE READING
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