Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol‐fed rabbits

  title={Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol‐fed rabbits},
  author={Ana Luiza Pamplona Mosimann and Danilo Wilhelm-Filho and Edson Luiz da Silva},
Ilex paraguariensis aqueous extract (mate) is an antioxidant‐rich beverage widely consumed in South American countries. Here we questioned whether mate could reduce the progression of atherosclerosis in 1% cholesterol‐fed rabbits. New Zealand White male rabbits (n = 32) were divided into four groups: control (C, n = 5), control‐mate (CM, n = 5), hypercholesterolemic (HC, n = 11) and hypercholesterolemic‐mate (HCM, n = 11). The daily water and mate extract consumption was approximately 400 ml… 

Aqueous Extract of Yerba Mate Tea Lowers Atherosclerotic Risk Factors in a Rat Hyperlipidemia Model

The results suggest that Mate tea exerts strong antioxidant and lipid‐lowering effects, prevents hepatic fatty deposition, and regulates the expression of lipid metabolic regulators, and can therefore be used to reduce the risk of atherosclerosis.


The results showed that aqueous extract of I. paraguariensis was able to reverse the oxidative stress caused by the cafeteria diet on serum, as well as significantly reduce lipid peroxidation in liver and brain tissues.

Consumption of yerba mate ( Ilex paraguariensis ) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy.

It was concluded that intake of yerba mate infusion improved the lipid parameters in normolipidemic and dyslipidemic subjects and provided an additional LDL-cholesterol reduction in hypercholesterolemic subjects on statin treatment, which may reduce the risk for cardiovascular diseases.

Efeito da erva-mate (Ilex paraguariensis A. St. Hil.) sobre o perfil metabólico em ratos alimentados com dietas hiperlipídicas

The objective of this study is to evaluate the effect of mate tea infusion on the metabolic profi le in rats fed on hyperlipidic diets. Thirty six adult, male, Wistar rats were studied. These were

Influence of yerba mate tea (Ilex paraguariensis) in improving some lipolytic enzymes of high-fat diet-induced obese rats

Daily administration of yerba mate tea to obese rats significantly decreased weight gain and alleviated the histopathological changes which seen in liver of obese rats, and intake of yersinia mate tea may benefit patients who suffer from hyperlipidemia.

Consumption of mate tea (Ilex paraguariensis) decreases the oxidation of unsaturated fatty acids in mouse liver

The results suggest that treatment with mate tea was able to protect unsaturated fatty acids from oxidation and may have selective protective effects within the body, especially on the liver.

Maté Tea Inhibits In Vitro Pancreatic Lipase Activity and Has Hypolipidemic Effect on High‐fat Diet‐induced Obese Mice

Results suggest that maté tea could be a potentially therapeutic alternative in the treatment of obesity caused by a high‐fat diet, and in vitro lipase activity and on obesity in obese mice models were examined.



Low density lipoprotein oxidation is inhibited by extracts of Ilex paraguariensis.

Water extracts of Ilex paraguariensis were more potent antioxidants than either ascorbic acid, or butylated hydroxytoluene, and the substances implicated in this antioxidant activity are largely nondializable.

Antioxidant effects of Ilex paraguariensis: induction of decreased oxidability of human LDL in vivo.

  • A. Gugliucci
  • Biology
    Biochemical and biophysical research communications
  • 1996
It is concluded that antioxidants in Ilex paraguariensis are absorbed and reach sufficient high levels in plasma to inhibit copper-induced LDL autoxidation by increasing aqueous-phase antioxidant capacity.

Antioxidant effects of an aqueous extract of Ilex paraguariensis.

The results suggest that ingestion of extracts of Ilex paraguariensis could contribute to increase the antioxidant defense of an organism against free radicals attack.

Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats.

A high abundance of microbial metabolites shows that the bioavailability of chlorogenic acid depends largely on its metabolism by the gut microflora, and their potential importance in explaining the biological effects of dietary polyphenols is emphasized.

Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low-density lipoprotein oxidation.

Ip is a rich source of polyphenols and has antioxidant properties comparable to those of green tea which merit further in vivo intervention and cross-sectional studies.