Aquaporins in the kidney: from molecules to medicine.

@article{Nielsen2002AquaporinsIT,
  title={Aquaporins in the kidney: from molecules to medicine.},
  author={S{\o}ren Nielsen and J{\o}rgen Fr{\o}kiaer and David J. Marples and Tae-Hwan Kwon and Peter Agre and Mark A. Knepper},
  journal={Physiological reviews},
  year={2002},
  volume={82 1},
  pages={
          205-44
        }
}
The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of how water specifically crosses biological membranes. In the kidney, at least seven aquaporins are expressed at distinct sites. AQP1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. AQP2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water channel. AQP3 and… CONTINUE READING

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