Aquaporins in health and disease.

  title={Aquaporins in health and disease.},
  author={L. S. King and Masato Yasui and Peter Agre},
  journal={Molecular medicine today},
  volume={6 2},
The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is… CONTINUE READING