Aquaporins as targets for drug discovery.

  title={Aquaporins as targets for drug discovery.},
  author={Antonio Frigeri and Grazia Paola Nicchia and Maria Svelto},
  journal={Current pharmaceutical design},
  volume={13 23},
The intracellular hydric balance is an essential process of mammalian cells. The water movement across cell membranes is driven by osmotic and hydrostatic forces and the speed of this process is dependent on the presence of specific aquaporin water channels. Since the molecular identification of the first water channel, AQP1, by Peter Agre's group, 13 homologous members have been found in mammals with varying degree of homology. The fundamental importance of these proteins in all living cells… CONTINUE READING

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