Aquaporins and Brain Tumors

  title={Aquaporins and Brain Tumors},
  author={Rosario Maugeri and Gabriella Schiera and Carlo Maria Di Liegro and Anna Fricano and Domenico Gerardo Iacopino and Italia Di Liegro},
  booktitle={International journal of molecular sciences},
Brain primary tumors are among the most diverse and complex human cancers, and they are normally classified on the basis of the cell-type and/or the grade of malignancy (the most malignant being glioblastoma multiforme (GBM), grade IV). Glioma cells are able to migrate throughout the brain and to stimulate angiogenesis, by inducing brain capillary endothelial cell proliferation. This in turn causes loss of tight junctions and fragility of the blood-brain barrier, which becomes leaky. As a… CONTINUE READING
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