Aquaporin water channels: molecular mechanisms for human diseases1

@article{Agre2003AquaporinWC,
  title={Aquaporin water channels: molecular mechanisms for human diseases1},
  author={Peter Agre and David E. Kozono},
  journal={FEBS Letters},
  year={2003},
  volume={555}
}
Although water is the major component of all biological fluids, the molecular pathways for water transport across cell membranes eluded identification until the discovery of the aquaporin family of water channels. The atomic structure of mammalian AQP1 illustrates how this family of proteins is freely permeated by water but not protons (hydronium ions, H3O+). Definition of the subcellular sites of expression predicted their physiological functions and potential clinical disorders. Analysis of… Expand
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TLDR
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TLDR
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Aquaporins in health and disease.
TLDR
The role of AQPs in health and disease is examined based on the latest currently available evidence based upon the latest technological improvements associated with the methods employed to evaluate their functions. Expand
Aquaporins as potential drug targets
TLDR
Phenotype studies suggest that AQP may be potential drug targets for not only new diuretic reagents for various forms of pathological water retention, but also targets for novel therapy of brain edema, inflammatory disease, glaucoma, obesity, and cancer. Expand
A Brief Survey of Aquaporins and Their Implications for Renal Physiology
Aquaporins (AQPs) are an important family of proteins that efficiently channel water through the cell membranes. Although water can diffuse across biological membranes at measurable rates,Expand
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TLDR
Aquaporins expression is linked to numerous pathologies including tumor metastasis, fluid dysregulation, and traumatic injury, and the targeted modulation of AQPs therefore presents an opportunity to develop novel treatments for diverse conditions. Expand
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