Aquaporin gene therapy for disorders of cholestasis?


The involvement of aquaporin (AQP) water channels in epithelial fluid transport is supported by compelling evidence, largely from transgenic AQP knockout mice and some from humans with loss-of-function mutations. It is instructive to think about the role of AQPs in epithelial fluid transport in three scenarios, as depicted in Fig. 1. In glandular fluid… (More)
DOI: 10.1002/hep.28623


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