Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.

@article{Krane2001Aquaporin5M,
  title={Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.},
  author={Carissa M. Krane and Christopher N. Fortner and Arthur R Hand and Dennis W. McGraw and John N. Lorenz and Susan E. Wert and Jennifer E Towne and Richard J. Paul and Jeffrey A. Whitsett and A. G. G. Menon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 24},
  pages={
          14114-9
        }
}
Although aquaporin 5 (AQP5) is the major water channel expressed in alveolar type I cells in the lung, its actual role in the lung is a matter of considerable speculation. By using immunohistochemical staining, we show that AQP5 expression in mouse lung is not restricted to type I cells, but is also detected in alveolar type II cells, and in tracheal and bronchial epithelium. Aqp5 knockout (Aqp5(-/-)) mice were used to analyze AQP5 function in pulmonary physiology. Compared with Aqp5(+/+) mice… CONTINUE READING
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