Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice.

Abstract

The astrocyte water channel aquaporin-4 (AQP4) regulates extracellular space (ECS) K(+) concentration ([K(+)]e) and volume dynamics following neuronal activation. Here, we investigated how AQP4-mediated changes in [K(+)]e and ECS volume affect the velocity, frequency, and amplitude of cortical spreading depression (CSD) depolarizations produced by surface… (More)
DOI: 10.1002/glia.22853

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