Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia.

  title={Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia.},
  author={Tong Da and Alan S Verkman},
  journal={Investigative ophthalmology & visual science},
  volume={45 12},
PURPOSE Water channel aquaporin (AQP)-4 is expressed in Muller cells in retina, which are similar to astroglial cells in the central nervous system, where AQP4 deletion protects against cytotoxic brain edema after cerebral ischemia. A transient ischemia-reperfusion model was used to determine whether AQP4 deletion in mice protects the retina. METHODS Retinal function and morphology were assessed in wild-type versus AQP4-deficient mice after ischemic damage produced by a 45- to 60-minute… CONTINUE READING


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