Aquaporin-4 expression is increased in oedematous human brain tumours.

@article{Saadoun2002Aquaporin4EI,
  title={Aquaporin-4 expression is increased in oedematous human brain tumours.},
  author={Samira Saadoun and Marios C Papadopoulos and Derek A. C. Davies and Sanjeev Krishna and B. A. Bell},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2002},
  volume={72 2},
  pages={
          262-5
        }
}
Aquaporin-4 (AQP4) is a highly conserved water channel protein. In rats, AQP4 is expressed in astrocyte foot processes and is important in brain water homeostasis. AQP4 expression has not been investigated in non-neoplastic human brain or oedematous brain tumours, where water homeostasis is disrupted. Therefore, immunohistochemistry was used to study AQP4 expression in non-neoplastic and neoplastic human brain and blood-brain barrier permeability was assessed using contrast enhanced computed… CONTINUE READING
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