Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: A combined MRI-histological study

@article{Tourdias2009Aquaporin4C,
  title={Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: A combined MRI-histological study},
  author={Thomas Tourdias and Iulius Dragonu and Yasutaka Fushimi and Mathilde S. A. Deloire and Claudine Boiziau and Bruno Brochet and Chrit Moonen and Klaus G. Petry and Vincent Dousset},
  journal={NeuroImage},
  year={2009},
  volume={47 2},
  pages={659-66}
}
Hydrocephalus features include ventricular dilatation and periventricular edema due to transependymal resorption of cerebrospinal fluid (CSF). Aquaporin 4 (AQP4), a water channel protein located at the blood-brain barrier, might facilitate the removal of this excess of water from the parenchyma into the blood. First, we hypothesized a link between AQP4 expression and the severity of hydrocephalus. We further hypothesized that movements of water through AQP4 could affect apparent diffusion… CONTINUE READING
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