Aquaporin 4 blockade improves survival of murine heart allografts subjected to prolonged cold ischemia.

Abstract

Prolonged cold ischemia storage (CIS) is a leading risk factor for poor transplant outcome. Existing strategies strive to minimize ischemia-reperfusion injury in transplanted organs, yet there is a need for novel approaches to improve outcomes of marginal allografts and expand the pool of donor organs suitable for transplantation. Aquaporins (AQPs) are a… (More)
DOI: 10.1111/ajt.14624

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